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Mantle cell lymphoma
3 associated genes
7 signs/symptoms
PROTEIN INTERACTIONS: 1
Bloom syndrome
1 OMIM reference -
1 associated gene
40 signs/symptoms
Mantle cell lymphoma
Bloom syndrome

ATM
(UniProt - OMIM)
 BLM
(UniProt - OMIM)
CCND1
(UniProt - OMIM)
IGH
(UniProt)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
ATM
(0.88)
BLM


Citations in the biomedical literature:


Mantle cell lymphoma
ATM CCND1 IGH
Bloom syndrome
BLM



Mantle cell lymphoma
Bloom syndrome

Synonym(s):
- LCM
- MCL
- Mantle zone lymphoma
Synonym(s):
- BSyn
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare eye disease
- Rare genetic disease
- Rare hematologic disease
- Rare immune disease
- Rare oncologic disease
- Rare skin disease
Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: adulthood
Average age of death: adult
Type of inheritance: multigenic/multifactorial
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: adult
Type of inheritance: autosomal recessive
External references:
No OMIM references
1 MeSH reference: D020522
External references:
1 OMIM reference -
1 MeSH reference: D001816
Mantle cell lymphoma
Bloom syndrome

Very frequent
- Hematologic / blood / lymphatic cancer
- Lymphadenopathy / polyadenopathies

Frequent
- Anorexia
- Asthenia / fatigue / weakness
- Bone marrow / medullar infiltration
- Splenomegaly
- Weight loss / loss of appetite / break in weight curve / general health alteration



Very frequent
- Acute diarrhea
- Anomalies of nose and olfaction
- Anomalies of skin, subcutaneous tissue and mucosae
- Autosomal recessive inheritance
- Chromosome breakage
- Delayed bone age
- Dolichocephaly / scaphocephaly
- Erythema / erythematous lesions / erythroderma / polymorphous erythema
- Flat cheek bones / malar hypoplasia
- Immunodeficiency / increased susceptibility to infections / recurrent infections
- Intrauterine growth retardation
- Irregular / in bands / reticular skin hyperpigmentation
- Narrow face
- Nasal congestion / sinusitis / rhinitis / rhinorrhea
- Neoplasms / tumors
- Repeat respiratory infections
- Short stature / dwarfism / nanism

Frequent
- Abnormal cry / voice / phonation disorder / nasal speech
- Face / facial anomalies
- Hypoplastic mandibula / partial absence of the mandibula
- Short / small nose
- Skin photosensitivity
- Telangiectasiae of the skin

Occasional
- Acute leukemia
- Agammaglobulinemia / hypogammaglobulinemia / B-cell deficiency
- Anodontia / oligodontia / hypodontia
- Digestive neoplasm / tumor / carcinoma / cancer
- Failure to thrive / difficulties for feeding in infancy / growth delay
- Hyperhidrosis / increased sweating
- Ichthyosis / ichthyosiform dermatitis
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Irregular / patchy skin hypopigmentation
- Lymphoma
- Microcephaly
- Prominent / bat ears
- Sacral sinus / dimple
- Skin tumors / lumps / epidermal cysts
- Sterility / hypofertility
- Syndactyly of fingers / interdigital palm
- Upper limb polydactyly / hexadactyly